The majority of patients do not notice any significant changes until the 12-week mark with the oral semaglutide. It is a long-term medication, and most patients find a great change in the 6-12 months timeframe. These medications are to be used in conjunction with proper diet and exercise, including counting calories, monitoring water intake, and getting a minimum of 150 minutes of cardio per week. Injectable medications offer more rapid weight loss due to being available in much higher dosages. You may consider switching to an injectable medication if you're looking for faster results.